| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 381 | Ikerne | Spanish | Visitation. | F | |
| 382 | Ileanna | Spanish | Variant of Elena. | F | |
| 383 | Iliana | Spanish | Variant of Elena. | F | |
| 384 | Iluminada | Spanish | Illuminated. | F | |
| 385 | Imelda | Spanish | Powerful fighter. The name of a fourteenth-century Spanish saint. | F | |
| 386 | Immaculada | Spanish | The Immaculate Conception. | F | |
| 387 | Ines | Spanish | Meek. Chaste. Variant of Agnes. | F | |
| 388 | Inez | Spanish | Pure. Chaste. The Spanish version of Agnes. | F | |
| 389 | Inoceneia | Spanish | Innocent. | F | |
| 390 | Inocenta | Spanish | Innocent. | F | |
| 391 | Iratze | Spanish | Reference to the Virgin Mary. | F | |
| 392 | Irene | Spanish | Peace. | F | |
| 393 | Irune | Spanish | Reference to the Holy Trinity. | F | |
| 394 | Isa | Spanish | Beautiful. Diminutive of Isabel: Devoted to God. A Spanish variant of Elizabeth. | F | |
| 395 | Isabel | Spanish | Devoted to God. A Spanish variant of Elizabeth. | F | |
| 396 | Isabela | Spanish | Variant of Elizabeth. My God is bountiful;God of plenty. | F | |
| 397 | Isabella | Spanish | My God is bountiful. God of plenty. Devoted to God. A Spanish variant of Elizabeth. | F | |
| 398 | Isabelle | Spanish | Variant of Isabel: Devoted to God. A Spanish variant of Elizabeth. | F | |
| 399 | Ishbel | Spanish | Variant of Isabel: Devoted to God. A Spanish variant of Elizabeth. | F | |
| 400 | Isidora | Spanish | Gifted with many ideas. | F | |